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K.G.M. Savelkouls

Recent publications
  • Beaumont, J. E. J., Barbeau, L. M. O., Ju, J., Savelkouls, K. G., Bouwman, F. G., Zonneveld, M. I., Bronckaers, A., Kampen, K. R., Keulers, T. G. H., & Rouschop, K. M. A. (2024). Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKa activation. Journal of Extracellular Vesicles, 13(7), Article e12449. https://doi.org/10.1002/jev2.12449
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  • Sánchez-Castillo, A., Heylen, E., Hounjet, J., Savelkouls, K. G., Lieuwes, N. G., Biemans, R., Dubois, L. J., Reynders, K., Rouschop, K. M., Vaes, R. D. W., De Keersmaecker, K., Lambrecht, M., Hendriks, L. E. L., De Ruysscher, D. K. M., Vooijs, M., & Kampen, K. R. (2024). Correction: Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer. British Journal of Cancer, 130(4), Article 701. https://doi.org/10.1038/s41416-024-02603-z
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  • Sanchez-Castillo, A., Heylen, E., Hounjet, J., Savelkouls, K. G., Lieuwes, N. G., Biemans, R., Dubois, L. J., Reynders, K., Rouschop, K. M., Vaes, R. D. W., De Keersmaecker, K., Lambrecht, M., Hendriks, L. E. L., De Ruysscher, D. K. M., Vooijs, M., & Kampen, K. R. (2024). Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer. British Journal of Cancer, 130(4), 568-584. https://doi.org/10.1038/s41416-023-02553-y
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  • Beaumont, J. E. J., Ju, J., Barbeau, L. M. O., Demers, I., Savelkouls, K. G., Derks, K., Bouwman, F. G., Wauben, M. H. M., Zonneveld, M. I., Keulers, T. G. H., & Rouschop, K. M. A. (2024). GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development. Radiotherapy and Oncology, 190, Article 109968. https://doi.org/10.1016/j.radonc.2023.109968
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  • Keulers, T. G., Koch, A., van Gisbergen, M. W., Barbeau, L. M. O., Zonneveld, M. I., de Jong, M. C., Savelkouls, K. G. M., Wanders, R. G., Bussink, J., Melotte, V., & Rouschop, K. M. A. (2022). ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer. Autophagy, 18(8), 1898-1914. https://doi.org/10.1080/15548627.2021.2008690
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  • Keulers, T. G., Libregts, S. F., Beaumont, J. E. J., Savelkouls, K. G., Bussink, J., Duimel, H., Dubois, L., Zonneveld, M. I., Lopez-Iglesias, C., Bezstarosti, K., Demmers, J. A., Vooijs, M., Wauben, M., & Rouschop, K. M. A. (2021). Secretion of pro-angiogenic extracellular vesicles during hypoxia is dependent on the autophagy-related protein GABARAPL1. Journal of Extracellular Vesicles, 10(14), Article e12166. https://doi.org/10.1002/jev2.12166
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  • Jutten, B., Keulers, T. G., Peeters, H. J. M., Schaaf, M. B. E., Savelkouls, K. G. M., Compter, I., Clarijs, R., Schijns, O. E. M. G., Ackermans, L., Teernstra, O. P. M., Zonneveld, M. I., Colaris, R. M. E., Dubois, L., Vooijs, M. A., Bussink, J., Sotelo, J., Theys, J., Lammering, G., & Rouschop, K. M. A. (2018). EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition. Autophagy, 14(2), 283-295. https://doi.org/10.1080/15548627.2017.1409926
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  • Keulers, T. G., Schaaf, M. B. E., Peeters, H. J. M., Savelkouls, K. G. M., Vooijs, M. A., Bussink, J., Jutten, B., & Rouschop, K. M. A. (2015). GABARAPL1 is required for increased EGFR membrane expression during hypoxia. Radiotherapy and Oncology, 116(3), 417-422. https://doi.org/10.1016/j.radonc.2015.06.023
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  • Schaaf, M. B., Jutten, B., Keulers, T. G., Savelkouls, K. G., Peeters, H. J., van den Beucken, T., van Schooten, F. J., Godschalk, R. W., Vooijs, M., & Rouschop, K. M. (2015). Canonical autophagy does not contribute to cellular radioresistance. Radiotherapy and Oncology, 114(3), 406-412. https://doi.org/10.1016/j.radonc.2015.02.019
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  • Jutten, B., Keulers, T. G., Schaaf, M. B. E., Savelkouls, K., Theys, J., Span, P. N., Vooijs, M. A., Bussink, J., & Rouschop, K. M. A. (2013). EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival. Radiotherapy and Oncology, 108(3), 479-483. https://doi.org/10.1016/j.radonc.2013.06.033
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