NASH Non Alcoholic Steato Hepatitis (non-alcoholic fatty liver disease)
Recent publications
Vermeulen, I., Li, M., van Mourik, H., Yadati, T., Eijkel, G., Balluff, B., Godschalk, R., Temmerman, L., Biessen, E. A. L., Kulkarni, A., Theys, J., Houben, T., Cillero-Pastor, B., & Shiri-Sverdlov, R. (2025). Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis. FEBS Journal, 292(7), 1781-1797. https://doi.org/10.1111/febs.17358
Heymann, C. J. F., Mak, A. L., Holleboom, A. G., Verheij, J., Shiri-Sverdlov, R., van Mil, S. W. C., Tushuizen, M. E., Koek, G. H., & Grefhorst, A. (2024). The plasma lipidome varies with the severity of metabolic dysfunction-associated steatotic liver disease. Lipids in Health and Disease, 23(1), Article 402. https://doi.org/10.1186/s12944-024-02380-x
Li, M., Houben, T., Bitorina, A. V., Meesters, D. M., Israelsen, M., Kjærgaard, M., Koek, G. H., Hendrikx, T., Verbeek, J., Krag, A., Thiele, M., & Shiri-Sverdlov, R. (2024). Plasma cathepsin D as an early indicator of alcohol-related liver disease. JHEP Reports, 6(9), Article 101117. https://doi.org/10.1016/j.jhepr.2024.101117
Westheim, A. J. F., Stoffels, L. M., Dubois, L. J., van Bergenhenegouwen, J., van Helvoort, A., Langen, R. C. J., Shiri-Sverdlov, R., & Theys, J. (2023). The Modulatory Effects of Fatty Acids on Cancer Progression. Biomedicines, 11(2), Article 280. https://doi.org/10.3390/biomedicines11020280
van Mourik, H., Li, M., Baumgartner, S., Theys, J., & Shiri-Sverdlov, R. (2022). All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma. Biomedicines, 10(10), 1-19. Article 2351. https://doi.org/10.3390/biomedicines10102351
Westheim, A. J. F., Stoffels, L. M., Dubois, L. J., van Bergenhenegouwen, J., van Helvoort, A., Langen, R. C. J., Shiri-Sverdlov, R., & Theys, J. (2022). Fatty Acids as a Tool to Boost Cancer Immunotherapy Efficacy. Frontiers in nutrition, 9, Article 868436. https://doi.org/10.3389/fnut.2022.868436
Mokkala, K., Gustafsson, J., Vahlberg, T., Vreugdenhil, A. C. E., Ding, L., Shiri-Sverdlov, R., Plat, J., & Laitinen, K. (2022). Serum CathepsinD in pregnancy: Relation with metabolic and inflammatory markers and effects of fish oils and probiotics. Nutrition Metabolism and Cardiovascular Diseases, 32(5), 1292-1300. https://doi.org/10.1016/j.numecd.2022.02.011
Groenen, A. G., La Rose, A. M., Li, M., Bazioti, V., Svendsen, A. F., Kloosterhuis, N. J., Ausema, A., Pranger, A., Heiner-Fokkema, M. R., Niezen-Koning, K. E., Houben, T., Shiri-Sverdlov, R., & Westerterp, M. (2022). Elevated granulocyte-colony stimulating factor and hematopoietic stem cell mobilization in Niemann-Pick type C1 disease. Journal of Lipid Research, 63(2), Article 100167. https://doi.org/10.1016/j.jlr.2021.100167
Ding, L., Oligschlaeger, Y., Shiri-Sverdlov, R., & Houben, T. (2022). Nonalcoholic Fatty Liver Disease. In A. von Eckardstein, & C. J. Binder (Eds.), Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets (Vol. 270, pp. 233-269). Springer. https://doi.org/10.1007/164_2020_352
Baumgartner, S., & Shiri-Sverdlov, R. (2021). NASH and Systemic Complications: From Basic to Clinical Research. Biomedicines, 9(12), Article 1913. https://doi.org/10.3390/biomedicines9121913