Dr Frits Prinzen (F.W.)
Research profile
Basic and applied research in the area of cardiac pump function and how it is influenced by pacemaker therapies.
Research projects
Projects since 2010:
- Endocardial vs. epicardial cardiac resynchronization therapy in canine hearts with left bundle branch block. Supported by EBR Systems (Sunnyvale) € 120.000
- Congestive Heart failure and Arrhythmia (COHFAR) consortium with the Center of Translational and Molecular Medicine and Medtronic. (2010-2015) Budget of Prof. Prinzen: € 2.500.000.
- Reduction of ischemia / reperfusion injury by pre- and postconditioning. Research program aiming to decrease the morbidity after cardiac surgery and to improve the survival and outcome after cardiac arrest. Dutch Heart Foundation grant for Junior Staffmember for Dr. W.Y.R. Vanagt. (2011-2014) € 250.000
- Towards better pacing therapies in patients with congenital heart disease. Dutch Heart Foundation grant for Pediatric Investigator for I.E. van Geldorp MD, PhD. (2011-2012) € 82.000
- ZonMW Clinical Fellowship Dr. K. Vernooy: “Synchronous ventricular pacing heart using novel left ventricular septum pacing site 2011-2015; € 160.000
- Effect of vernakalant on electrophysiology and pump function in canine LBBB hearts. Supported by MSD. (2011-2012); € 93.000.
- “Assessment of electrical and mechanical dyssynchrony in canine hearts with left bundle branch block”. Supported by Biologics Delivery Systems Group, Cordis Corporation. € 35,000. (2012-2013)
- Noninvasive Patient-Specific Cardiovascular Simulation to Optimize Diagnosis and Pacemaker Treatment of Heart Failure. Dekker grant for Junior Postdoc of Dutch Heart Foundation for Dr. J. Lumens. (2013-2016) € 250.000
Recent publications
Other publications
Publications
PhD theses
Prinzen FW. Gradients in regional myocardial blood flow, metabolism and mechanics across the ischemic left ventricular wall.
Rijksuniversiteit Limburg, Maastricht,1982.
Co-promotor with:
Delhaas T. Regional subepicardial mechanics under normoxic and ischemic circumstances- relations with hemodynamics, and regional electrical activation and oxygen uptake. Rijksuniversiteit Limburg, Maastricht,1993.
Roekaerts P. Alpha2 agonists and myocardial ischemia.
Universiteit Maastricht, Maastricht, 1997
Lawrence CL. Dexmedetomidine as anesthetic adjuvant. Cardiovascular and anesthetic effects in animals and humans. Universiteit Maastricht, Maastricht, 1998
van Oosterhout MFM. Local myocardial adaptations during chronic ventricular pacing. Universiteit Maastricht, Maastricht 1999.
Winner of the Hamburger Award of the Dutch Physiological Society for best PhD thesis in 1999.
Aelen FWL. Quantification of 3D cardiac wall deformation using magnetic resonance tagging. Maastricht, 1999.
Wyman BT. Mechanical evaluation of the paced heart using tagged magnetic resonance imaging. Johns Hopkins University, Baltimore (USA), 1999.
Peschar M. Reverse remodeling in bradycardia induced volume overload. The role of optimizing the pacing site. Universiteit Maastricht, 2003.
Kerckhoffs R.C.P. Depolarization wave and mechanics in the paced heart. Model and experiment. Technische Universiteit Eindhoven, 2003.
Vernooy K. Dyssynchronopathy and the role of cardiac resynchronization therapy. Universiteit Maastricht, 2006.
H. Willigers. Anesthesiological strategies to modulate the surgical stress response. A focus on the cardiovascular consequences. Universiteit Maastricht 2007
W.Y.R Vanagt. Pacing induced dyssynchrony. Blessing or curse? Universiteit Maastricht 2007
Winner of the Hamburger Award of the Dutch Physiological Society for best PhD thesis in 2008 and of the CARIM thesis award for the best PhD thesis in CARIM (2007-2008).
Promotor with:
B.W.L. DeBoeck. Echo-physiologic aspects of dyssynchrony and resynchronization. Utrecht University, 2009.
L.M.F. Rademakers. Resynchronization of the ischemic asynchronous heart. Maastricht University 2010.
I.E. van Geldorp. Improving ventricular pacing in adults and children: To treat or to avoid dyssynchrony-induced cardiac failure. Maastricht University, 2012.
H.E. Blaauw. Stretch-mediated cardiac hypertrophy and extracellular matrix remodeling. Maastricht University, 2013.
Full papers
Prinzen FW, Van der Vusse GJ, Coumans WA, Kruger R, Verlaan CWJ, Reneman RS. The effect of elevated arterial free fatty acid concentrations on hemodynamic and myocardial metabolism and blood flow during ischemia. Basic Res Cardiol 76: 197-210, 1981.
Prinzen FW, Van der Vusse GJ, Reneman RS. Blood flow distribution in the left ventricular free wall in open-chest dogs. Basic Res Cardiol 76: 431-437,1981.
Van der Vusse GJ, Prinzen FW, Reneman RS. Myocardial substrate uptake. Bibl Anat 20: 497-502, 1981.
Van der Vusse GJ, Roemen THM, Prinzen FW, Reneman RS. The concentration of non-esterified fatty acids in biopsies from normoxic dog myocardium. Basic Res Cardiol 76: 389-393, 1981.
Van der Vusse GJ, Roemen THM, Prinzen FW, Coumans WA, Reneman RS. Uptake and accumulation of fatty acids in dog myocardium under normoxic and ischemic conditions. Circ Res 50: 538-546, 1982.
Prinzen FW, Arts T, Van der Vusse GJ, Reneman RS. Fiber shortening in the inner layers of the left ventricular wall as assessed from epicardial deformation during normoxia and ischemia. J Biomech 17: 801-811, 1984.
Prinzen FW, Van der Vusse GJ, Arts T, Roemen THM, Coumans WA, Reneman RS. Accumulation of non-esterified fatty acids in ischemic canine myocardium. Am J Physiol 247: H264-H272, 1984.
Prinzen FW, Arts T, Prinzen TT, Reneman RS. Relationship between myocardial fiber direction and segment shortening in the midwall of the canine left ventricle. Letter to the Editor. Circ Res 57: 909-910, 1985.
Prinzen TT, Arts T, Prinzen FW, Reneman RS. Mapping of epicardial deformation using a video processing technique. J Biomech 19: 263-273, 1986.
Prinzen FW, Arts T, Van der Vusse GJ, Coumans WA, Reneman RS. Gradients in fiber shortening and metabolism across the ischemic left ventricular wall. Am J Physiol 250: H255-H264, 1986.
Van der Vusse GJ, Van der Veen FH, Prinzen FW, Coumans WA, Van Bilsen M, Reneman RS. The effect of diltiazem on myocardial recovery after regional ischemia in dogs. Eur J Pharmacol 125: 383-394, 1986.
Prinzen FW, Alewijnse R, Van der Vusse GJ, Van der Nagel T, Kruger RTI, Reneman RS. Coronary artery stenosis controlled by distal perfusion pressure: description of the servo-system and time dependent changes in regional myocardial blood flow. Basic Res Cardiol 82: 375-387, 1987.
Van der Vusse GJ, Prinzen FW, Van Bilsen M, Engels W, Reneman RS. Accumulation of lipids and lipid-intermediates in the heart during ischemia. Basic Res Cardiol 82:157-167,1987.
Reneman RS, Prinzen FW, Van Bilsen M, Engels W, Van der Vusse GJ. Non-esterified fatty acid (NEFA) metabolism and membrane disorders in myocardial ischemia. Recent Adv Cardiovasc Dis 8:S4-7,1987.
Reneman RS, Prinzen FW, Engels W, Van Bilsen M, Van der Vusse GJ. Arachidonic acid metabolism during myocardial ischemia. Prog Appl Microcirc 12:152-169,1987 .
Daemen MJAP, Thijssen HHW, Van Essen H, Vervoort-Peters HTM, Prinzen FW, Struyker-Boudier HAJ, Smits JFM. Liver blood flow measurement in the rat: The electromagnetic vs. the microsphere and the clearance methods. J Pharmacol Methods 21: 287-297, 1989.
Prinzen FW, Arts T, Hoeks APG, Reneman RS. Discrepancies between myocardial blood flow and fiber shortening in the ischemic border zone as assessed with video mapping of epicardial deformation. Eur J Physiol (Pfluegers Arch) 415: 220-229, 1989.
Prinzen FW, Augustijn CH, Arts T, Allessie MA, Reneman RS. Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am J Physiol 259: H300-H308, 1990.
Arts T, Bovendeerd PHM, Prinzen FW, Reneman RS. Relation between left ventricular cavity pressure and volume and systolic fiber stress and strain in the wall. Biophys J 59: 93-102, 1991.
Augustijn CH, Arts T, Prinzen FW, Reneman RS. Mapping the sequence of contraction of the canine left ventricle. Eur J Physiol (Pfluegers Arch) 419: 529-533, 1991.
Prinzen FW, Augustijn CH, Allessie MA, Arts T, Delhaas T, Reneman RS. The time sequence of electrical and mechanical activation during spontaneous beating and ectopic stimulation. Eur Heart J 13: 535-543, 1992.
Delhaas T, Arts T, Bovendeerd PHM, Prinzen FW, Reneman RS. Subepicardial fiber strain and stress as related to left ventricular pressure and volume. Am J Physiol 264: H1548-H1559, 1993.
Delhaas T, Arts T, Prinzen FW, Reneman RS. Relation between regional electrical activation time and subepicardial fiber strain in the canine left ventricle. Eur J Physiol (Pfluegers Arch) 423: 78-87, 1993.
Arts T, Prinzen FW, Snoeckx LHEH, Rijcken JM, Reneman RS. Adaptation of cardiac structure by mechanical feedback in the environment of the cell: A model study. Biophysical J 66: 953-961, 1994.
Delhaas T, Arts T, Prinzen FW, Reneman RS. Regional fibre stress-fibre strain area as estimate of regional oxygen demand in the canine heart. J Physiol (London) 477.3: 481-496, 1994
Prinzen FW, Glenny RW. Developments in non-radioactive microsphere techniques for blood flow measurements. Cardiovasc Res 28: 1467-1475, 1994.
Prinzen FW, Cheriex EM, Delhaas T, Van Oosterhout MFM, Arts T, Wellens HJJ, Reneman RS. Asymmetric thickness of the left ventricular wall due to asynchronous electrical activation. A study in patients with left bundle branch block and in dogs with ventricular pacing. Am Heart J 130: 1045-1053, 1995.
Van Oosterhout MFM, Willigers HMM, Reneman RS, Prinzen FW. Validation of the fluorescent microsphere technique for measurement of organ perfusion with a simplified sample processing method. Am J Physiol 269: H725-H733, 1995.
Lawrence C, Prinzen FW, De Lange S. Effects of dexmedetomidine on the balance of myocardial energy requirement and oxygen supply and demand. Anesth Analg 82: 544-550, 1996
Roekaerts PMHJ, Prinzen FW, Willigers HMM, De Lange S. Coronary vascular effects of dexmedetomidine during reactive hyperemia in the anesthetized dog. J Cardiothor Vasc Anesth 10: 619-626, 1996
Roekaerts PMHJ, Prinzen FW, Willigers HMM, De Lange S. The effect of alpha2-adrenergic stimulation with mivazerol on myocardial blood flow and function during coronary stenosis in anesthetized dogs. Anesth Analg, 82: 702-711, 1996.
Roekaerts PMHJ, Prinzen FW, Willigers HMM, De Lange S. Beneficial effects of dexmedetomidine on ischaemic myocardium of anesthetized dogs. Br. J. Anesthesiol 77: 427-429, 1996.
Prinzen FW, Van Oosterhout MFM, Arts T, Reneman RS. Local functional and structural changes in the myocardium during ventricular pacing. J Intervent Cardiol 9: 319-326, 1996.
Lawrence CJ, Prinzen FW, De Lange S. The effect of dexmedetomidine on nutrient organ blood flow. Anesth Analg 83: 1160-1165, 1996.
Arts T, Prinzen FW, Snoeckx LHEH, Reneman RS. A model approach to the adaptation of cardiac structure by mechanical feedback in the environment of the cell. Adv Exp Med Biol 382: 217-228, 1996.
Delhaas T, Arts T, Prinzen FW, Reneman RS. Regional electrical activation and mechanical function in the partially ischemic left ventricle of the dog. Am J Physiol 271: H2411-H2420, 1996.
Aelen FWL, Arts T, Sanders DGM, Thelissen GRP, Muijtjens AMM, Prinzen FW, Reneman RS. Relation between torsion and cross-sectional area change in the human left ventricle. J Biomechanics 30: 207-212, 1997.
Roekaerts PMHJ, Lawrence CJ, Prinzen FW, De Lange S. Alleviation of the peripheral hemodynamic effects of dexmedetomidine by the calcium channel blocker isradipine. Acta Anaesthesiol. Scand. 41: 364-370, 1997.
Mulder ALM, Van Golde J, Prinzen FW, Van Straaten H, Blanco C. Cardiac output distribution in the chick embryo from stage 36 to 45. Cardiovasc. Res. 34: 525-528, 1997.
Lawrence CJ, Prinzen FW, de Lange S. Hemodynamic and coronary vascular effects of dexmedetomidine in the anesthetized goat. Acta Anaesthesiol. Scand. 41: 830-836, 1997.
Mulder ALM, Van Golde J, Prinzen FW, Blanco C. Cardiac output distribution in response to hypoxia in the chick embryo in the second half of the incubation time. J. Physiology (London) 1998;508.1:281-287.
McVeigh ER, Prinzen FW, Wyman BT, Tsitlik JE, Halperin HR, Hunter WC. Mapping of asynchronous mechanical activation of the paced heart with tagged MRI. Magn. Res. Med. 1998;39:507-513.
Van Oosterhout MFM, Prinzen FW, Sakurada S, Glenny RW, Hales JRS. Fluorescent microspheres are superior to radioactive microspheres in chronic blood flow measurements. Am. J. Physiol. 1998;275:H110-H115.
Van Oosterhout MFM, Prinzen FW, Arts T, et al. Asynchronous electrical activation induces inhomogeneous hypertrophy of the left ventricular wall. Circulation 1998;98:588-595.
Delhaas T, Arts T, Prinzen FW, Reneman RS. Estimates of regional work in the canine left ventricle. Progr Biophys Mol Biol 69: 273-287, 1998
Prinzen FW, van Oosterhout MFM, Vanagt WYR, Storm C, Reneman RS. Optimization of ventricular function by improving the activation sequence during ventricular pacing. PACE 1998, 21: 2256-2260
Wyman BT, Hunter WC, Prinzen FW, McVeigh ER. Mapping propagation of mechanical activation in the paced heart with MRI tagging. Am. J. Physiol. 1999;276:H881-H891.
van Golde JM, Mulder TA, Scheve E, Prinzen FW, Blanco CE. Hyperoxia and local organ blood flow in the developing chick embryo. J. Physiol. (London) 1999;515 (part 1):243-248.
Prinzen FW, Hunter WC, Wyman BT, McVeigh ER. Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging. J. Am. Coll. Cardiol. 1999; 33:1735-1742.
Aelen FWL, Arts T, Sanders DGM, Thelissen GRP, Prinzen FW, Reneman RS. Kinematic analysis of left ventricular deformation in myocardial infarction using magnetic resonance cardiac tagging. Int. J. Cardiac Imag. 1999; 15:241-251.
Delhaas T, Prinzen FW. Sequelae of DDD pacing in patients with pulmonary infundibular stenosis. Am J Cardiol 1999; 84:1142. (letter to the editor)
Prinzen FW, Bassingthwaighte, JB. Blood flow distributions by microsphere deposition methods. Cardiovasc. Res. 2000; 45: 13-21,
van Oosterhout MFM, Arts T, Muijtjens AM, Reneman RS, Prinzen FW. Remodeling by ventricular pacing in hypertrophying dog hearts. Cardiovasc Res. 2001; 49:771-778.
Verbeek XA, Willigers JM, Prinzen FW, Peschar M, Ledoux LA, Hoeks AP. High-resolution functional imaging with ultrasound contrast agents based on RF processing in an in vivo kidney experiment. Ultrasound Med Biol. 2001; 27:223-233.
Wyman BT, Hunter WC, Prinzen FW, Faris OP, McVeigh ER. Effects of single- and biventricular pacing on temporal and spatial dynamics of ventricular contraction. Am J Physiol 2002; 282: H372-H379.
van Oosterhout MFM, Arts T, Bassingthwaighte JB, Reneman RS, Prinzen FW. Relation between local myocardial growth and blood flow during chronic ventricular pacing. Cardiovasc. Res. 2002; 53:831-40.
Prinzen FW, Peschar M. Relation between the pacing induced sequence of activation and left ventricular pump function in animals (review). PACE 2002; 25:484-98.
Verbeek XAAM, Vernooy K, Peschar M, van der Nagel T, van Hunnik A, Prinzen FW. Quantification of interventricular asynchrony during LBBB and ventricular pacing. Am J Physiol. 283: H1370-H1378, 2002.
Van der Toorn A, Barenburg P, Snoep G, Van der Veen FH, Delhaas T, Prinzen FW, Maessen J, Arts T. Transmural gradients of cardiac myofiber shortening in aortic valve stenosis patients using MRI-tagging. Am J Physiol 283: H1609-H1615, 2002
Willigers HM, Prinzen FW, Roekaerts PM, de Lange S, Durieux ME. Dexmedetomidine Decreases Perioperative Myocardial Lactate Release in Dogs. Anaesth Analg 96:657-664,2003
Peschar M, de Swart H, Michels KJ, Reneman RS, Prinzen FW. Left ventricular septal and apex pacing for optimal pump function in canine hearts. J Am Coll Cardiol 41: 1218-1226, 2003.
Arts T, Bovendeerd P, Delhaas T, Prinzen FW. Modeling the relation between cardiac pump function and myofiber mechanics. J. Biomech. 36: 731-736, 2003
Kerckhoffs RCP, Bovendeerd PHM, Kotte JCS, Prinzen FW, Smits K, Arts T. Homogeneity of cardiac contraction despite physiological asynchrony of depolarization: a model study. Ann. Biomed. Eng. 31: 536-547, 2003.
Peschar M, Vernooy K, Vanagt WYR, Reneman RS, Vos MA, Prinzen FW. Absence of reverse electrical remodeling during regression of volume overload hypertrophy in canine ventricles. Cardiovasc. Res. 58: 510-517, 2003.
Verbeek XAAM, Vernooy K, Peschar M, Cornelussen RNM, Prinzen FW. Intraventricular resynchronization for optimal left ventricular function during pacing in experimental left bundle branch block. J Am Coll Cardiol 42: 558-567, 2003.
Kerckhoffs RCP, Faris OP, Bovendeerd PHM, Prinzen FW, Smits K, McVeigh ER, Arts T. Timing of depolarization and contraction in the paced canine ventricle: model and experiment. J. Cardiovasc. Electrophysiol. 14: S188-S195, 2003.
Vernooy K, Verbeek XAAM, Peschar M, Prinzen FW. Relation between abnormal ventricular impulse conduction and heart failure. J. Interv. Cardiol. 16: 557-562, 2003.
Kerckhoffs RCP, Faris OP, Bovendeerd PHM, Prinzen FW, Smits K, McVeigh ER, Arts T. Intra- and interventricular asynchrony of electromechanics in the ventricularly paced heart. J. Engin. Math. 47: 201-216, 2003.
Cornelussen RN, Vanagt WY, Prinzen FW, Snoeckx LH. Proteins involved in salvage of the myocardium. Adv Exp Med Biol. 543:277-91, 2003.
Delhaas T, Kotte J, van der Toorn A, Snoep G, Prinzen FW, Arts T. Increase in left ventricular torsion to shortening ratio in children with valvular aortic stenosis. Magn. Res. Med. 51: 135-139, 2004.
Prinzen FW, Vernooy K, Cornelussen RN. Cardiac memory and cortical memory: do learning patterns in neural networks impact on cardiac arrhythmias? Letter to the Editor. Circulation 2004 109: e226.
Peschar M, Vernooy K, Cornelussen RN, Verbeek XAAM, Reneman RS, Vos MA,Prinzen FW. Structural, electrical and mechanical remodeling of the canine heart in AV-block and LBBB. Eur. Heart J. Supplements 6 (suppl D): D61-D65, 2004
Vanagt WY, Verbeek XAAM, Delhaas T, Mertens L, Daenen WJ, Prinzen FW. The Left ventricular apex is the Optimal Site for Pediatric Pacing: Correlation with Animal Experience of animal experience. Pacing Clin Electrophysiol. 27:837-843, 2004.
Breithardt G, Priori SG, Borggrefe M, Breithardt O-A, Ehreth J, Faerestrand S,
Gronda E, Hasenfuss G, Mäkijärvi M, Ohm O-J, Prinzen FW, Stellbrink C, Smiseth O, Tande PM, Tavazzi L. Cardiac Resynchronization and Defibrillation Therapies – International Clinical and Scientific Update. Hjerteforum 4: 50-52, 2004.
Prinzen FW. Experimental left bundle branch block: studies on pathophysiology and resynchronization. Hjerteforum 4: 57-59, 2004.
Willigers HM, Prinzen FW, Roekaerts PM. Comparison of the effects of dexmedetomidine and esmolol on myocardial oxygen consumption in dogs. Eur J Anaesthesiol. 21:957-66, 2004.
Vernooy K, Verbeek XAAM, Peschar M, Crijns HJGM, Arts T, Cornelussen RNM,Prinzen FW, Left Bundle Branch Block Induces Ventricular Remodeling and Functional Septal Hypoperfusion. Eur. Heart J, 26: 91-98, 2005.
Vanagt WY, Verbeek XAAM, Delhaas T, Gewillig M. Mertens L, Wouters P, Meyns B, Daenen WJ, Prinzen FW Acute hemodynamic benefit of left ventricular apex pacing in children. Ann. Thor. Surg. 79:932-936, 2005.
Arts T, Delhaas T, Bovendeerd P, Verbeek X, Prinzen FW. Implementing adaptation rules results in self-shaping of heart and circulation, the CircAdapt model. Am. J. Physiol. 288:H1943-54, 2005
Kerckhoffs RCP, Faris OP, Bovendeerd PHM, Prinzen FW, Smits K, McVeigh ER, Arts T. Electromechanics of the paced left ventricle simulated by a straightforward mathematical model: comparison with experiments. Am J Physiol 2005; 289:H1889-97.
Sweeney MO, Prinzen FW. A New Paradigm for Physiologic Ventricular Pacing.
J Am Coll Cardiol 2006; 47:282– 8.
Sen S, Rose C, Ytrebo LM, Davies NA, Nedredal GI, Drevland SS, Kjonno M, Prinzen FW, Hodges SJ, Deutz NE, Williams R, Butterworth RF, Revhaug A, Jalan R. Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Crit Care Med. 2006 Jan;34(1):158-64.
Vernooy K, Delhaas T, Cremer OL, Di Diego JM, Oliva A, Timmermans C, Volders PG,Prinzen FW, Crijns HJGM, Antzelevitch C, Kalkman CJ, Rodriguez L-M, Brugada R. Electrocardiographic Changes predicting Sudden Death in Propofol Related Infusion Syndrome. Heart Rhythm 2006; 3:131-137
Verbeek XA, Auricchio A, Yu Y, Ding J, Pochet T, Vernooy K, Kramer A, Spinelli J,Prinzen FW. Tailoring cardiac resynchronization therapy using interventricular asynchrony. Validation of a simple model. Am J Physiol. 290: H968-H977, 2006
Vernooy K, Dijkman B, Cheriex EC, Prinzen FW, Crijns HJGM. Ventricular Remodeling During Long-term Right Ventricular Pacing Following His Bundle Ablation. Am J Cardiol 97:1223-1227, 2006.
Willigers HM, Prinzen FW, Roekaerts PM. The effects of esmolol and dexmedetomidine on myocardial oxygen consumption during sympathetic stimulation in dogs. J Cardiothorac Vasc Anesth. 2006 Jun;20(3):364-70
Vanagt WY, Cornelussen RN, Poulina QP, Blaauw E, Vernooy K, Cleutjens JP, Van Bilsen M, Delhaas T, Prinzen FW. Pacing-induced dys-synchrony preconditions rabbit myocardium against ischemia / reperfusion injury. Circulation, 114[suppl I]:
I-264–I-269, 2006.
Ytrebo LM, Sen S, Rose C, Davies NA, Nedredal GI, Fuskevaag O-M, Ten Have GAM,Prinzen FW, Williams R, Deutz NE, Rajiv Jalan, Revhaug A. Systemic and regional haemodynamics in pigs with acute liver failure and the effect of albumin dialysis. Scand. J. Gastroenterol. 2006; 11:1350-60.
Vernooy K, Verbeek, XAAM, Cornelussen RNM, Dijkman B, Crijns HJGM, Arts T, Prinzen FW. Calculation of effective VV-interval facilitates optimization of AV-delay and VV-interval in cardiac resynchronization therapy. Heart Rhythm 2007; 4:75-82.
Babiker FA, Lips DJ, Delvaux E, Zandberg P, Janssen BJ, Prinzen F, van Eys G, Grohe C, Doevendans PA. Oestrogen modulates cardiac ischaemic remodelling through oestrogen receptor-specific mechanisms. Acta Physiol. 2007;189:23-31.
Alders DJ, Cornelussen RN, Prinzen FW, Specht PA, Noble MI, Drake-Holland AJ, de Kanter FJ, van Beek JH. Regional sympathetic denervation affects the relation between local canine myocardial blood flow and oxygen consumption. Exp Physiol. Exp Physiol. 2007, 92:541-8.
Vanagt WY, Cornelussen RN, Baynham, TC, Van Hunnik A, Poulina QP, Babiker F, Spinelli J, Delhaas T, Prinzen FW. Pacing-induced dyssynchrony during early reperfusion reduces infarct size. J Am Coll Cardiol, 2007 49:1813-9.
Vernooy K, Cornelussen RN, Verbeek XA, Vanagt WY, van Hunnik A, Arts T, Kuiper M, Crijns HJ, Prinzen FW. Cardiac resynchronization therapy cures dyssynchronopathy in canine left bundle-branch block hearts. Eur Heart J. 2007; 28(17):2148-55
Vanagt WY, Prinzen FW, Delhaas T. Reversal of right ventricular pacing-induced heart failure by left ventricular apical pacing. New Eng J Med 357:2637-8, 2007.
De Boeck BWL, Meine M, Leenders GE, Teske AJ, Van Wessel H, Kirkels JH, Prinzen FW, Doevendans PA, Cramer MJM. Practical and conceptual limitations of tissue Doppler imaging to predict reverse remodelling in cardiac resynchronisation therapy. Eur. J. Heart Failure, 10: 281–290, 2008.
Vanagt WY, Prinzen FW, Delhaas T. Physiology of cardiac pacing in children – the importance of the ventricular pacing site. PACE 31:S24–S27, 2008.
Auricchio A, Prinzen FW. Cardiac Resynchronization Therapy: The more pacing sites, the better the outcome? J. Am. Coll. Cardiol (editorial), 2008; 51:1463-5.
Zanon F, Bacchiega E, Rampin L, Aggio S, Baracca E, Pastore G, Marotta T, Corbucci G, Rubello D, Prinzen FW. Direct His-bundle pacing preserves coronary perfusion compared with right ventricular apical pacing: a prospective, cross-over mid-term study. Europace 10(5):580-7, 2008.
Kerckhoffs RCP, Lumens J, Vernooy K, Omens JH, Mulligan LJ, Delhaas T, Arts T, McCulloch AD, Prinzen FW. Cardiac Resynchronization: insight from experimental and computational models. Progr. Biophys. Mol. Biol. 97 (2008) 543–561.
De Boeck BWL, Kirn B, Teske AJ, Hummeling RW, Doevendans PA, Cramer MJ,Prinzen FW. Three-dimensional mapping of mechanical activation patterns, contractile dyssynchrony and dyscoordination by two-dimensional strain
echocardiography. Rationale and design of a novel software toolbox. Cardiovasc. Ultrasound 6:22, 2008.
Kirn B, Jansen A, Bracke F, Van Gelder B, Starc V, Arts T, Prinzen FW. Myocardial internal stretch fraction discriminates between reverse remodeling of DCM and ICM patients upon cardiac resynchronization. Am. J. Physiol. 2008; 295:H640-646.
Auricchio A, Prinzen FW. Update on the pathophysiological basics of cardiac resynchronization therapy. Europace. 2008 ;10:797-800.
Rademakers LM, de Boeck BWL, Maessen JG, Prinzen FW. Development of Strategies for Guiding Cardiac Resynchronization Therapy. Heart Failure Clin 2008; 4: 333–345.
Sweeney M, Prinzen FW. Ventricular Pump Function and Pacing: Physiologic and Clinical Integration. (review) Circulation: Arrhythmia and Electrophysiol 2008; 1; 127-139.
Prinzen FW, Auricchio A. Is echocardiographic assessment of dyssynchrony useful to select candidates for cardiac resynchronization therapy?: Echocardiography Is Not Useful Before Cardiac Resynchronization Therapy if QRS Duration Is Available. (review) Circulation: Cardiovasc Imaging. 2008;1:70-78.
Driesen RB, Verheyen FK, Schaart G, De Maziere A, Viebahn C, Prinzen FW, Lenders M-H, Debie W, Totzeck A, Ramaekers FCS. Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its downregulation during dedifferentiation. Cardiovasc. Pathol. 18 (2009) 19–27.
Van Geldorp IE, Vanagt WY, Bauersfeld U, Tomaske M, Prinzen FW, Delhaas T. Chronic left ventricular pacing preserves left ventricular function in children. Pediatric Cardiol. 2009, 30:125-32
De Boeck BWL; Teske AJ; Meine M; Leenders GE, Cramer MJ, Prinzen FW; Doevendans PA. Septal rebound stretch reflects the functional substrate to cardiac resynchronization therapy and predicts volumetric and neurohormonal response. Eur. J. Heart Fail. 2009 11: 863-871
Van Deursen C, Van Geldorp I, Rademakers, L.M. Van Hunnik A, Kuiper M, Klersy C, Auricchio A, Prinzen FW. Left ventricular endocardial pacing improves resynchronization therapy in canine LBBB hearts. Circulation: Arrhythmias and Electrophysiology; 2009: 2:580-587
Mills RW, Cornelussen RN, Mulligan LJ, Strik M, Rademakers LM, Skadsberg ND, van Hunnik A, Kuiper M, Lampert A, Delhaas T, Prinzen FW. Left ventricular septal and left ventricular apical pacing chronically maintain cardiac contractile coordination, pump function and efficiency. Circulation: Arrhythmias and Electrophysiology; 2009 2:571-579.
Lumens J, Arts T, Broers B, Boomars KA, van Paassen P, Prinzen FW, Delhaas T. Right Ventricular Free Wall Pacing Improves Cardiac Pump Function in Severe Pulmonary Arterial Hypertension: a Computer Simulation Analysis. Am J. Physiol. 2009; 297:H2196-205.
Arts T, Prinzen FW, Delhaas T.(2009). Potentials and limitations of ventricular torsion as indicator of cardiac function. Conf Proc IEEE Eng Med Biol Soc. 1: 181-184.
Prinzen FW. Imaging or imagination of cardiac mechanics? Conf Proc IEEE Eng Med Biol Soc. 2009;1:166-9.
Van Geldorp IE, Vernooy K, Delhaas T, Prins M, Crijns HJ, Prinzen FW, Dijkman B. Beneficial Effects of Biventricular Pacing in Chronically Right Ventricular Paced Patients without Severe Heart Failure. Europace 2010;12:223-229.
Porciani CM, Lilli A, Cappelli F, Pappone A, Perini AP, Pieragnoli P, Ricciardi G, Rao CM, Prinzen FW, Michelucci A, Padeletti L. Echo/Doppler-derived time intervals are able to predict left ventricular reverse remodeling after cardiac resynchronization therapy. J Cardiovasc Med (Hagerstown). 2010, 11:157-63
Delhaas T, Prinzen FW. RV or BiV pacing in repaired Tetralogy of Fallot? (editorial comment) Heart Rhythm 2010; 7:351-352.
Babiker FA, Lorenzen-Schmidt I, Mokelke E, Vanagt WY, Delhaas T, Waltenberger J, Cleutjens JP, Prinzen FW. Long term protection and mechanism of pacing-induced postconditioning in the heart. Basic Res. Cardiol. 2010; 105:523-33.
Arts T, Prinzen FW, Delhaas T, Milles J, Rossi A, Clarysse P. Mapping Displacement and Deformation of the Heart With Local Sine-Wave Modeling. IEEE Trans Med Imaging. 2010; 29:1114-1123
De Boeck BWL, Teske AJ, Leenders GE, Mohamed Hoesein FAA, Loh P, van Driel VJ, Doevendans PA, Prinzen FW, Cramer MJ. Detection and Quantification by Deformation Imaging of the Functional Impact of Septal Compared to Free Wall Preexcitation in the Wolff-Parkinson-White Syndrome, Am. J. Cardiol. 106:539-546, 2010.
Rademakers LM, van Kerckhoven R, van Deursen CJM, Strik M, van Hunnik A, Kuiper M, Lampert A, Klersy C, Leyva F, Maessen JG, Auricchio A, Prinzen FW. Myocardial infarction does not preclude electrical and hemodynamic benefits of CRT in dyssynchronous canine hearts. Circulation Arrhythmia& Electrophysiol, 3:361-368, 2010
Blaauw E., van Nieuwenhoven FA, Willemsen P, Delhaas T, Prinzen FW, Snoeckx LH, van Bilsen M, van der Vusse GJ. Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes. Am. J. Physiol. 299: H780–H787, 2010
Van Geldorp IE, Delhaas T, Hermans B, Vernooy K, Broers B, Klimusina J, Regoli F, Faletra FF, Moccetti T, Gerritse B, Cornelussen R, Settels JJ, Crijns HJGM, Auricchio A,Prinzen FW. Comparison of a non-invasive arterial pulse contour technique and echo Doppler aorta velocity-time-integral on stroke volume changes in optimization of CRT. Europace 13: 87-95, 2011.
Hanssen SJ, Lubbers T, Hodin CM, Prinzen FW, Buurman WA, Jacobs MJ. Hemolysis results in impaired intestinal microcirculation and intestinal epithelial cell injury. World J Gastroenterol. 2011;17:213-8.
Klimusina J, De Boeck BW, Leenders GE, Faletra FF, Prinzen F, Averaimo M, Pasotti E, Klersy C, Moccetti T, Auricchio A. Redistribution of left ventricular strain by cardiac resynchronization therapy in heart failure patients. Eur J Heart Fail. 2011; 13:186-194
Kuijpers NHL, Potse M, van Dam P, ten Eikelder HMM, Verheule S, Prinzen FW, Schotten U. Mechano-Electrical Coupling Influences Onset and Perpetuation of Atrial Fibrillation during Acute Atrial Dilatation. Heart Rhythm 8:429 – 436; 2011
Auricchio A, Prinzen FW. Non-responders to Cardiac Resynchronization Therapy: The magnitude of the problem and the issues. Circ. J. 75:521-7; 2011
Prinzen FW, Vernooy K, DeBoeck BWL, Delhaas T. Mechano-energetics of the asynchronous and resynchronized heart. Heart Fail. Rev. 16:215-24, 2011
van Geldorp IE, Vanagt WY, Prinzen FW, Delhaas T Chronic ventricular pacing in children: towards prevention of dyssynchrony. Heart Fail. Rev. 16:305-14, 2011
Cornelussen R, Splett V, Klepfer R, Stegemann B, Kornet L, Prinzen FW. Electrical therapies beyond pacing for treatment in heart failure. Heart Fail. Rev. 16:315-25, 2011
Prinzen FW, Houthuizen P. The CRT monopoly game: return to start without dyssynchrony bonus? Circ J 2011;75:1053-4
Prinzen FW. Cardiac Resynchronization Therapy in Heart Failure (book review). Circulation 2011; 123: e416-e417
Strik M. Ploux S, Vernooy K, Prinzen FW. Cardiac Resynchronization Therapy: Refocus on Electrical Substrate. Circ J 2011, 75:1297-304
Leyva F, Foley PW, Chalil S, Ratib K, Smith RE, Prinzen F, Auricchio A. Cardiac resynchronisation therapy guided by late gadolinium-enhancement cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2011; 13:29.
Foley PW, Chalil S, Ratib K, Smith R, Prinzen F, Auricchio A, Leyva F. Fluoroscopic left ventricular lead position and the long-term clinical outcome of cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2011 Jul;34(7):785-97.
Bogaard MD, Houthuizen P, Bracke FA, Doevendans PA, Prinzen FW, Meine M, van Gelder BM. Maximum Rate Of Left Ventricular Pressure Rise (LV dP/dtmax) Predicts 1-Year Survival Of Patients With Cardiac Resynchronization Therapy. Eur. J. Heart Fail. 13: 1126-32, 2011.
Bacharova Ljuba, Mateasik A, Krause R, Prinzen FW, Auricchio, Potse M. The effect of reduced intercellular coupling on electrocardiographic signs of left ventricular hypertrophy. J. Electrocardiol. 44:571-6, 2011
Wecke L, van Deursen CJM, Bergfeldt L, Prinzen FW. Repolarization changes in patients with heart failure receiving cardiac resynchronization therapy – signs of cardiac memory. J. Electrocardiol, 44:590-598, 2011
Van Geldorp IE, Delhaas T, Gebauer RA, Frias P, Tomaske M, Friedberg MK, Tisma-Dupanovic S, Elders J, Früh A, Gabbarini F, Kubuš P, Illikova V, Tsao S, Blank AC, Hiippala A, Sluysmans T, Karpawich P, Clur S-A, Ganame X, Collins KK, Dann G, Thambo J-B, Trigo C, Nagel B, Papagiannis J, Rackowitz A, Marek J, Nürnberg J-H, Vanagt W, Prinzen FW, Janousek J. Impact of the permanent ventricular pacing-site on LV function in children: a retrospective multi-center survey; Heart 97:2051-2055, 2011.
Mischi M, Kaklidou F, Houthuizen P, Aben JP, Prinzen FW, Bracke F, van den Bosch H, Korsten HH. Three-dimensional quantification of regional left-ventricular dyssynchrony by magnetic resonance imaging. Conf Proc IEEE Eng Med Biol Soc. 2011:2646-9
Leenders GE, Lumens J, Cramer MJ, De Boeck BWL, Doevendans PA, Delhaas T,Prinzen FW. Septal deformation patterns delineate mechanical dyssynchrony and regional differences in contractility: analysis of patient data using a computer model. Circulation: Heart Failure (2012) 5: 87-96
Strik M, Rademakers LM, van Deursen C, van Hunnik A, Kuiper M, Klersy C, Auricchio A, Prinzen FW. Endocardial Left Ventricular Pacing Improves Cardiac Resynchronization Therapy in Chronic Asynchronous Infarction and Heart Failure Models. Circulation: Arrhythmia&Electrophysiology, (2012) 5: 191-200
Prinzen FW, Auricchio A. The "Missing" Link Between Acute Hemodynamic Effect and Clinical Response. J Cardiovasc Transl Res. (2012) 5:188–195
Strik M, Regoli F, Auricchio A, Prinzen FW. Electrical and mechanical ventricular activation during left bundle branch block and resynchronization. J Cardiovasc Transl Res. (2012) 5:117–126
Kuijpers NHL, Hermeling E, Bovendeerd PHM, Delhaas T, Prinzen FW. Modeling Cardiac Electromechanics and Mechano-Electrical Coupling in Dyssynchronous and Failing Hearts. J Cardiovasc Transl Res. (2012) 5:159–169
Prinzen FW, Houthuizen P, Bogaard MD, van Gelder B, Bracke F, Cramer MJ, Leenders GE, Meine M. Is Acute Hemodynamic Response a Predictor of Long-Term Outcome in Cardiac Resynchronization Therapy? J Am Coll Cardiol. (2012) 59(13):1198.
Wecke L, van Hunnik A, Thompson T, DiCarlo L, Zdeblick M, Auricchio A, Prinzen FW. Networked Multi-Electrode Left Ventricular Pacing Lead For Avoidance of Phrenic Nerve Stimulation. Heart Rhythm (2012) 9: 789-95
Leenders GE, DeBoeck BWL, Teske AJ, Meine M, Bogaard MD, Prinzen FW, Doevendans PA, Cramer MJ. Septal Rebound Stretch is a Strong Predictor of Outcome After Cardiac Resynchronization Therapy. J Cardiac Fail. (2012) 5:404-12.
Svendsen M, Prinzen FW, Das MK, Berwick Z, Rybka M,Tune JD, Combs W, Edward J. Berbari EJ, Kassab GS. Bi-ventricular pacing improves pump function only with adequate myocardial perfusion in canine hearts with pseudo-LBBB. Exp. Biol. Med. 2012;237:644-51
Gorcsan J 3rd, Prinzen FW. Understanding the Cardiac Substrate and the Underlying Physiology: Implications for Individualized Treatment Algorithm. Heart Rhythm 2012 (8 Suppl):S18-26.
Kalder J, Keschenau P, Hanssen SJ, Greiner A, Vermeulen Windsant IC, Kennes LN, Tolba R, Prinzen FW, Buurman WA, Jacobs MJ, Koeppel TA. The impact of selective visceral perfusion on intestinal macrohemodynamics and microhemodynamics in a porcine model of thoracic aortic cross-clamping. J Vasc Surg. 2012, 56:149-58.
Van Deursen CJM, Strik M, Rademakers LM, van Hunnik A, Kuiper M, Wecke L, Crijns HJGM, Vernooy K, Prinzen FW. Vectorcardiography as a tool for easy optimization of cardiac resynchronization in canine LBBB hearts. Circulation A&E 2012; 5:544-52
Lumens J, Leenders GE, Cramer MJ, De Boeck BWL, Doevendans PA, Prinzen FW,Delhaas T. Mechanistic evaluation of echocardiographic dyssynchrony indices: patient data combined with multiscale computer simulations. Circulation Cardiovasc. Imag. 2012, 5: 491-499
Houthuizen P, Van Garsse LAFM, Poels TT, de Jaegere P, van der Boon RMA, Swinkels BM, ten Berg JM, van der Kley F, Schalij MJ, Baan Jr J, Cocchieri R, Brueren GRG, van Straten AHM, den Heijer P, Bentala M, van Ommen V, Kluin J, Stella PR, Prins MH, Maessen JG, Prinzen FW. Left bundle branch block induced by transcatheter aortic valve implantation increases risk of death. Circulation 2012, 126:720-8.
Daubert JC, Saxon L, Adamson PB, Auricchio A, Berger RD, Beshai JF, Breithard O, Brignole M, Cleland J, DeLurgio DB, Dickstein K, Exner DV, Gold M, Grimm RA, Hayes DL, Israel C, Leclercq C, Linde C, Lindenfeld JA, Merkely B, Mont L, Murgatroyd F, Prinzen F, Saba SF, Shinbane JS, Singh J, Tang AS, Vardas PE, Wilkoff BL, Zamorano JL. 2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Europace 14:1236-1286, 2012.
Daubert JC, Saxon L, Adamson PB, Auricchio A, Berger RD, Beshai JF, Breithard O, Brignole M, Cleland J, Delurgio DB, Dickstein K, Exner DV, Gold M, Grimm RA, Hayes DL, Israel C, Leclercq C, Linde C, Lindenfeld J, Merkely B, Mont L, Murgatroyd F, Prinzen F, Saba SF, Shinbane JS, Singh J, Tang AS, Vardas PE, Wilkoff BL, Zamorano JL. 2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Heart Rhythm. 2012 Sep;9(9):1524-76.
Hermeling E, Delhaas T, Prinzen FW, Kuijpers NHL. Mechano‑electrical feedback explains T-wave morphology and optimizes cardiac pump function: insight from a multiscale model. Prog. Biophys. Mol. Biol. 110: 359-371, 2012
Babiker FA, van Golde J, Vanagt WY, Prinzen FW. Pacing postconditioning: Impact of pacing algorithm, gender and diabetes on its myocardial protective effects. J Cardiovasc Transl Res. 2012, 5: 727-34
Potse M, Krause D, Bacharova L, Krause R, Prinzen FW, Auricchio A. Similarities and differences between ECG signs of left bundle branch block and left-ventricular uncoupling. Europace 2012, 5: v33-v39.
Houthuizen P, van der Boon RM, Van Garsse LA, Prinzen FW, de Jaegere P. Why permanent pacemaker implantation after transcatheter aortic valve implantation does not affect long-term clinical outcome. J Am Coll Cardiol. 2012;60:2339-2340.
Janoušek J, van Geldorp IE, Krupičková S, Rosenthal E, Nugent K, Tomaske M, Früh A, Elders J, Hiippala A, Kerst G, Gebauer RA, Kubuš P, Frias P, Gabbarini F, Clur S.-A, Nagel B, Ganame J, Papagiannis J, Marek J, Tisma-Dupanovic S, Tsao S, Nürnberg J.-H, Wren C, Friedberg M, de Guillebon M, Prinzen FW, Delhaas T. Permanent Cardiac Pacing in Children - Choosing the Optimal Pacing-site: A Multi-Center Study. Circulation 2013; 127:613-623.
Mafi Rad M, Blaauw Y, Prinzen FW, Vernooy K. The role of acute invasive haemodynamic measurements in cardiac resynchronization therapy: looping towards prediction of long-term response and therapy optimization. Eur J Heart Fail. 2013; 15:247-249.
Wieneke H, Rickers S, Velleuer J, Bruck G, Bai Z, Kocks C, Pierre- Grandjean A, Lenihan T, Jung P, Erbel R, Prinzen FW, Kisker E. Leadless Pacing Using Induction Technology. Impact of Pulse Shape and Geometric Factors on Pacing Efficiency. Europace 2013, 15:453-459