PhD Defence Marco Antonio Chavez Alfaro

Keywords: Cardiometabolic health, Type 2 diabetes (T2D), Cardiovascular diseases (CVD), Dietary products
 

"Dietary Strategies for Cardiometabolic Health: Effects of Collagen Hydrolysate and Nuts in Overweight and Obese Adults"

Adopting a healthy lifestyle is crucial for reducing the risk of developing type 2 diabetes (T2D) and cardiovascular diseases (CVDs), which remain the leading causes of death worldwide. To support lifestyle modifications, identifying ingredients or products with cardiometabolic benefits is essential. This thesis investigates the effects of three dietary products (a porcine-derived collagen hydrolysate, almonds, and mixed nuts) on various cardiometabolic health parameters in populations at elevated risk of developing T2D and CVD. Furthermore, the relationship between glycemic variability and fructosamine concentrations in adults without diabetes was also investigated. In summary, porcine-derived collagen hydrolysates showed minimal effects on cardiometabolic risk markers. Almond consumption reduced ambulatory systolic blood pressure (BP) and BP variability but did not impact other vascular markers, while mixed nuts improved serum lipid and lipoprotein profiles, subclasses, and composition, potentially supporting cardiovascular health. Glycemic variability in nondiabetic individuals showed weak associations with fructosamine concentrations. These findings support the integration of certain dietary products, particularly nuts, into dietary strategies for enhancing cardiometabolic health.

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