PhD conferral Ms Anne Gemmink, MSc.
Supervisors: prof.dr. M.K.C. Hesselink, prof.dr. P. Schrauwen
Co-supervisor: prof.dr. M.A.M.J. van Zandvoort
“Myocellular lipid droplets and insulin sensitivity: A microscopy approach”
Keywords: Type 2 diabetes, insulin resistance, fat accumulation in muscles
Insulin resistance lies at the basis of type 2 diabetes. Insulin resistance is often paired with increased fat deposits in muscle tissue, which some people claim to be the cause; however, highly trained and insulin-sensitive athletes also store a lot of fat in their muscles, which serves to counter this causal relationship. This dissertation examines the distinct characteristics of fat accumulation in insulin-sensitive and insulin-resistant states using techniques such as microscopy. The most important conclusion is that normal lipid droplets that come into contact with the protein PLIN5 are associated with higher insulin sensitivity.
Also read
-
PhD Defence Max Hubertus Mathias Carolus Scheepers
"Reducing the Impact of the Surgical Knife in (Para-) Thyroid Surgery Innovative Preoperative Diagnostics in Minimally Invasive Parathyroid and Thyroid Surgery"
1 Jul -
PhD Defence Yanyun Zhang
"Microbial degradation of structurally diverse plant- derived compounds: insights from the in vitro colon system TIM-2"
1 Jul -
PhD Defence Sara Maria Paula Lambrichts
"Cerebral Microvascular Dysfunction in a Rat Model of Heart Failure With Preserved Ejection Fraction"
1 Jul