Metabolism of the heart in health and disease
In this project, health-relevant features of metabolism in cardiomyocytes will be studied with metabolic modelling approaches. Many pathological conditions of the heart are known to have a metabolic component. However, while individual connections to metabolism have been studied, no systematic, comprehensive investigation of these complex connections has been carried out thus far.
This project presents an exciting opportunity to discover crucial connections between cardiomyopathies and metabolism that might improve medical treatment options.
Details
Project activities/type of research
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Metabolic modelling using genome scale metabolic models (in silico)
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Bioinformatics analyses focused on human cardiogenetics (in silico)
Programme
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Systems Biology (FSE)
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Maastricht Science Programme (FSE)
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Knowledge Engineering (FSE)
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Biomedical Sciences (FHML)
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Bachelor and Master level
Prior knowledge/skills required
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Basic molecular biology
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Basic human genetics
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Knowledge of/interest in metabolic modeling
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Knowledge of/interest in bioinformatics
Contact person/supervisor
Name: Michiel Adriaens, Assistant professor
Department: Maastricht Centre for Systems Biology