Dr D.G.J. Jennen

Diemar, M. G., Vinken, M., Teunis, M., Krul, C. A. M., Busquet, F., Zajac, J. D., Kandarova, H., Corvi, R., Rossi, M. Z., Kharina, A., Bryndum, L. S., Santillo, M., Bloch, D., Kucheryavenko, O., Panagiotakos, D., Rogiers, V., Beekhuijzen, M., Giusti, A., Najjar, A., ... Roggen, E. L. (2024). Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders. ATLA-Alternatives to laboratory animals, 52(2), 117-131. https://doi.org/10.1177/02611929231225730

Donovan, S. D. O., Cavill, R., Wimmenauer, F., Lukas, A., Stumm, T., Smirnov, E., Lenz, M., Ertaylan, G., Jennen, D. G. J., van Riel, N. A. W., Driessens, K., Peeters, R. L. M., & de Kok, T. M. C. M. (2023). Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data. PLOS ONE, 18(11), Article e0292030. https://doi.org/10.1371/journal.pone.0292030

Jiang, J., van Ertvelde, J., Ertaylan, G., Peeters, R., Jennen, D., de Kok, T. M., & Vinken, M. (2023). Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human in vitro data sets. Archives of Toxicology, 97(11), 2969-2981. https://doi.org/10.1007/s00204-023-03583-4

Bischoff, N. S., Proquin, H., Jetten, M. J., Schrooders, Y., Jonkhout, M. C. M., Briedé, J. J., van Breda, S. G., Jennen, D. G. J., Medina-Reyes, E. I., Delgado-Buenrostro, N. L., Chirino, Y. I., van Loveren, H., & de Kok, T. M. (2023). Correction: Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256. Nanomaterials, 13(21), Article 2888. https://doi.org/10.3390/nano13212888

Martens, M., Stierum, R., Schymanski, E. L., Evelo, C. T., Aalizadeh, R., Aladjov, H., Arturi, K., Audouze, K., Babica, P., Berka, K., Bessems, J., Blaha, L., Bolton, E. E., Cases, M., Damalas, D. ., Dave, K., Dilger, M., Exner, T., Geerke, D. P., ... Et al. (2023). ELIXIR and Toxicology: a community in development. F1000Research, 10(1), Article 1129. https://doi.org/10.12688/f1000research.74502.2

Gall, L., Jardi, F., Lammens, L., Piñero, J., Souza, T. M., Rodrigues, D., Jennen, D. G. J., de Kok, T. M., Coyle, L., Chung, S.-W., Ferreira, S., Jo, H., Beattie, K. A., Kelly, C., Duckworth, C. A., Pritchard, D. M., & Pin, C. (2023). A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity. CPT: Pharmacometrics and Systems Pharmacology, 12(10), 1511-1528. https://doi.org/10.1002/psp4.13029

Bischoff, N. S., Proquin, H., Jetten, M. J., Schrooders, Y., Jonkhout, M. C. M., Briede, J. J., van Breda, S. G., Jennen, D. G. J., Medina-Reyes, E. I., Delgado-Buenrostro, N. L., Chirino, Y. I., van Loveren, H., & de Kok, T. M. (2023). Reply to Kaminski, NE; Cohen, SM Comment on "Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256". Nanomaterials, 13(9), Article 1552. https://doi.org/10.3390/nano13091552

Rodrigues, D., van Kampen, R., van Bodegraven, A. A., Kleinjans, J. C. S., Jennen, D. G. J., & de Kok, T. M. (2022). Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Toxicology Letters, 371, 17-24. https://doi.org/10.1016/j.toxlet.2022.09.013

Verheijen, M., Sarkans, U., Wolski, W., Jennen, D., Caiment, F., Kleinjans, J., & HeCaToS Consortium (2022). Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds. Scientific data, 9(1), 699. https://doi.org/10.1038/s41597-022-01825-1

Nguyen, N., Jennen, D., & Kleinjans, J. (2022). Omics technologies to understand drug toxicity mechanisms. Drug Discovery Today, 27(11), Article 103348. https://doi.org/10.1016/j.drudis.2022.103348