Paul Wieringa (P.A.)
The current focus is on the development and application of 3D co-culture environment to combine peripheral neurons (sensory, motor, sympathetic, parasympathetic) with other tissue types in an organized and controlled manner. By incorporating optogenetic control of neural activity, the aim is to create controlled and functionally innervated tissue and to study the impact of neural stimulation on tissue health, disease, and regeneration. The end goal is to answer fundamental biological questions and generate new regenerative medicine strategies.
In addition, peripheral nerve repair remains an active area of research as well as the application of 3D in vitro culture systems for other possible appications.
Wieringa, P. A., de Pinho, A. R. G., Micera, S., van Wezel, R. J. A., & Moroni, L. (2018). Biomimetic Architectures for Peripheral Nerve Repair: A Review of Biofabrication Strategies. Advanced Healthcare Materials, 7(8), Article 1701164. https://doi.org/10.1002/adhm.201701164
More information about this publication
Santos, D., Wieringa, P., Moroni, L., Navarro, X., & Del Valle, J. (2017). PEOT/PBT Guides Enhance Nerve Regeneration in Long Gap Defects. Advanced Healthcare Materials, 6(3), Article 1600298. https://doi.org/10.1002/adhm.201600298
More information about this publication
Malheiro, A., Wieringa, P., Mota, C., Baker, M., & Moroni, L. (2016). Patterning Vasculature: The Role of Biofabrication to Achieve an Integrated Multicellular Ecosystem. ACS Biomaterial Science and Engineering, 2(10), 1694-1709. https://doi.org/10.1021/acsbiomaterials.6b00269
More information about this publication
Masaeli, E., Wieringa, P. A., Morshed, M., Nasr-Esfahani, M. H., Sadri, S., van Blitterswijk, C. A., & Moroni, L. (2014). Peptide functionalized polyhydroxyalkanoate nanofibrous scaffolds enhance Schwann cells activity. Nanomedicine-Nanotechnology Biology and Medicine, 10(7), 1559-1569. https://doi.org/10.1016/j.nano.2014.04.008
More information about this publication
Paul Wieringa (P.A.)
Assistant Professor
CTR
Institute MERLN
Fac. Health, Medicine and Life Sciences