Jacco Briedé (J.J.)
My main research interests include:
- Role of free radical mechanism in oxidative cell damage and chemopreventive action of dietary antioxidants e.g green tea polyphenols, vitamin C and flavonoids;
- Involvement of free radical formation and the relation with chemical composition and health effects of ambient particulate matter and nanomaterials;
- Cellular and mitochondrial free radical formation and the involvement in biological processes e.g. mitochondrial uncoupling and mitochondrial dysfunction caused by e.g. pharmaceuticals and drugs.
- In vivo- and in vitro detection of nitric oxide (NO) and investigations into its role in health- and disease-related mechanisms;
- Applications of toxicogenomics-related applications to unravel mechanisms liver-specific genotoxic and carcinogenic compounds including the development of in vitro alternatives for in vivo toxicology tests.
CIN - Brain miRNA’s as markers of drug induced changes in neural integrity
Testing mechanistic and placebo-controlled studies in which we will administer a psychedelic drug (i.e. psilocybin) that is known to affect neural integrity More »
INTERREG VLA-NED Herinneringen
Towards an earlier diagnosis of Alzheimers Disease (AD) More »
BE BASIC finalized
Biobased solutions for a sustainable society More »
EU FP7 - HeCaToS finalized
Hepatic and Cardiac Toxicity Systems modelling More »
Hepatocarcinogenesis finalized
Gene expression profiling of oxidative genotoxic compounds in hepatocarcinogenesis More »
miRNAno finalized
Toxicogenomic studies on engineered carbon nanomaterials
Proquin, H., Rodríguez-Ibarra, C., Moonen, C., Urrutia Ortega, I. M., Briedé, J. J., de Kok, T. M., van Loveren, H., & Irasema Chirino, Y. (2018). Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions. Mutagenesis, 33(3), 267-268. https://doi.org/10.1093/mutage/gey011
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Briede, J. J., Deferme, L., Wolters, J. E. J., Claessen, S. M. H., van den Beucken, T., Wagner, R. J., van Breda, S. G., & Kleinjans, J. C. S. (2018). A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases. Toxicology in Vitro, 48, 318-328. https://doi.org/10.1016/j.tiv.2018.02.006
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Briede, J., Proquin, H., de Kok, T. M., & van Loveren, H. (2018). Transcriptome responses in Caco-2 cells to micro- and nanoparticles in food-grade titanium dioxide (El 71) and potential impact on colon cancer development. Toxicology Letters, 295, S142-S143. https://doi.org/10.1016/j.toxlet.2018.06.727
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Cavill, R., Jennen, D., Kleinjans, J., & Briedé, J. (2016). Transcriptomic and metabolomic data integration. Briefings in Bioinformatics, 17(5), 891-901. https://doi.org/10.1093/bib/bbv090
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van Breda, S. G. J., Briede, J. J., & de Kok, T. M. C. M. (2019). Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals. Nutrients, 11(1), Article 61. https://doi.org/10.3390/nu11010061
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Deferme, L., Briede, J. J., Claessen, S. M. H., Cavill, R., & Kleinjans, J. C. S. (2015). Cell line-specific oxidative stress in cellular toxicity: A toxicogenomics-based comparison between liver and colon cell models. Toxicology in Vitro, 29(5), 845-855. https://doi.org/10.1016/j.tiv.2015.03.007
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Proquin, H., Rodriguez-Ibarra, C., Moonen, C. G. J., Urrutia Ortega, I. M., Briede, J. J., de Kok, T. M., van Loveren, H., & Chirino, Y. I. (2017). Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions. Mutagenesis, 32(1), 139-149. https://doi.org/10.1093/mutage/gew051
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Jacco Briedé (J.J.)
Assistant Professor
Toxicogenomics
GROW, School for Oncology & Reproduction
Fac. Health, Medicine and Life Sciences