H.H.H.W. Schmidt
COST action OpenMultiMed
H2020 FeatureCloud
H2020 REPO-TRIAL
ERC PoC SAVEBRAI
Langhauser, F., Casas, A. I., Dao, V.-T.-V., Guney, E., Menche, J., Geuss, E., Kleikers, P. W. M., López, M. G., Barabási, A.-L., Kleinschnitz, C., & Schmidt, H. H. H. W. (2018). A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection. NPJ systems biology and applications, 4, Article 8. https://doi.org/10.1038/s41540-017-0039-7
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Casas, A. I., Geuss, E., Kleikers, P. W. M., Mencl, S., Herrmann, A. M., Buendia, I., Egea, J., Meuth, S. G., Lopez, M. G., Kleinschnitz, C., & Schmidt, H. H. H. W. (2017). NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proceedings of the National Academy of Sciences of the United States of America, 114(46), 12315-12320. https://doi.org/10.1073/pnas.1705034114
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Aguirre-Plans, J., Pinero, J., Menche, J., Sanz, F., Furlong, L. I., Schmidt, H. H. H. W., Oliva, B., & Guney, E. (2018). Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology. Pharmaceuticals, 11(3), Article 61. https://doi.org/10.3390/ph11030061
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Gray, S. P., Jha, J. C., Kennedy, K., van Bommel, E., Chew, P., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2017). Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease. Diabetologia, 60(5), 927-937. https://doi.org/10.1007/s00125-017-4215-5
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Kleinschnitz, C., Mencl, S., Kleikers, P. W. M., Schuhmann, M. K., Lopez, M. G., Casas, A. I., Surun, B., Reif, A., & Schmidt, H. H. H. W. (2016). NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 36(9), 1508-1512. https://doi.org/10.1177/0271678X16657094
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Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W., & Jandeleit-Dahm, K. A. M. (2016). Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling. Arteriosclerosis Thrombosis and Vascular Biology, 36(2), 295-307. https://doi.org/10.1161/ATVBAHA.115.307012
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Casas, A. I., Dao, V. T.-V., Daiber, A., Maghzal, G. J., Di Lisa, F., Kaludercic, N., Leach, S., Cuadrado, A., Jaquet, V., Seredenina, T., Krause, K. H., Lopez, M. G., Stocker, R., Ghezzi, P., & Schmidt, H. H. H. W. (2015). Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Antioxidants & Redox Signaling, 23(14), 1171-1185. https://doi.org/10.1089/ars.2015.6433
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Kleikers, P. W. M., Hooijmans, C., Goeb, E., Langhauser, F., Rewell, S. S. J., Radermacher, K., Ritskes-Hoitinga, M., Howells, D. W., Kleinschnitz, C., & Schmidt, H. H. H. W. (2015). A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation. Scientific Reports, 5, Article 13428. https://doi.org/10.1038/srep13428
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Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., Barthel, K., Schuhmann, M. K., Herrmann, A. M., Meuth, S. G., Stoll, G., Meurer, S., Schrewe, A., Becker, L., Gailus-Durner, V., ... Schmidt, H. H. H. W. (2010). Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration. Plos Biology, 8(9), Article e1000479. https://doi.org/10.1371/journal.pbio.1000479
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Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E. L., Oettrich, J., Ruskovska, T., Gasparovic, A. C., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W., & Ghezzi, P. (2015). Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants & Redox Signaling, 23(14), 1144-1170. https://doi.org/10.1089/ars.2015.6317
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H.H.H.W. Schmidt
Professor of Pharmacology
Chairman Department of Pharmacology and Personalised Medicine
Pharmacology and Personalised Medicine
School for Mental Health & Neuroscience
Fac. Health, Medicine and Life Sciences