Keywords: Hemostasis, Laboratory assays, COVID-19, Anticoagulation
 

"Innovative applications of global assays of hemostasis"

In recent years, a shift has been initiated from traditional ‘unidimensional’ hemostatic assays towards more global assays of hemostasis, including viscoelastic assays and thrombin generation assays. These assays are considered to better represent the complete hemostatic status in a patient and have the potential to address several unmet laboratory challenges in complex pathologies. This thesis evaluates the application of global assays of hemostasis in two such patient cohorts, specifically COVID-19 patients admitted to the intensive care unit and high-risk patients following percutaneous coronary intervention (PCI). The findings in this thesis demonstrate the applicability of these assays to characterize the hemostatic abnormalities in critical COVID-19 disease. Furthermore, these assays appear of interest to detect and monitor anticoagulants in patients. Examples include the monitoring of heparin in severe COVID-19 patients and detecting anticoagulants in a post-PCI setting. Future research is required to further explore the clinical relevance of global assays of hemostasis in the presented and novel patient settings. This will further aid the shift towards a more global approach in hemostasis patient care.

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