Topic: Computable biological processes
In the upcoming seminar, two speakers will talk about computable biological processes. 
The event will be hosted online on Zoom. Contact Martina Summer-Kutmon (martina.kutmon@maastrichtuniversity.nl) if you want to join. 

Speakers

Aurélie Carlier, PhD
MERLN institute, UM

Title: From intracellular signaling to in silico clinical trials
Abstract: The complexity of the biochemical and biophysical features of cell signaling are truly remarkable. For example, signal specificity is not only determined by the type of downstream component but also by its temporal and spatial dynamics. Due to this complexity, disentangling the individual contributions and decoding the design principles of signaling dynamics is challenging and requires and interdisciplinary approach. In this talk, I will present how mechanistic and data-driven computational models can contribute to an improved fundamental understanding of cell signaling and tissue regeneration. I will discuss a number of models at various stages of use between the bench and bedside, giving a final outlook on in silico clinical trials, the digital patient, and computational models for regulatory approval.

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Egon Willighagen, PhD
Department of Bioinformatics - BiGCaT, NUTRIM, UM

Title: The Virtual Human Platform: smart algorithms and computational models
Abstract: Last year the Nederlandse WetenschapsAgenda project VHP4Safety started, aimed to develop a virtual human platform (VHP). The Platform will integrate existing and newly developed data from human studies, advanced in vitro models and computational models. The Platform will enable the prediction of potential harmful effects of chemicals and pharmaceuticals, including the role of gender, age and disease states. This presentation will focus on how we are building a platform that is sustainable, flexible, modular, and continuously growing and learning, using innovative bioinformatics approaches from previous projects.