Keywords: Obesity, Weight Loss, Diet, Genetic

"The Interaction between Inflammatory Properties of Diet and Genetic Variation in Body Weight Regulation"

A low-calorie diet has been a long-standing practice among nutritionists and dieticians as a core component of weight loss programs. However, the pitfall of this diet is the tendency to weight regain after weight loss is achieved. It is argued that inflammation affects weight to be regained. Inflammation is influenced by multiple factors such as diet (some nutrients have anti-inflammatory properties), genetic, and environmental exposure. This context is essential because people whose energy intake is restricted during a diet-induced weight loss program tend to reduce their intake of essential nutrients as well. This thesis developed a new dietary regime for weight loss with the aim not only to reduce calorie intake but also to reduce inflammation by improving nutrient intake during energy deficit. The thesis also shows that the individual response to a diet is influenced by variations in genes linked to inflammation.

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